In view of the reported co-signaling between integrin αvβ3 and PTEN and the expression of integrin αvβ3 on neuroblastoma capillaries and PTEN in the tumor cells, we next examined if there was association between expression of integrin αvβ3 on the tumor microvessels and the pattern of PTEN expression in these stage 3 neuroblastomas. Here, PTEN is linked to neuroblastoma.