Univarite analysis using Kaplan–Meier analysis evaluated significant impact of clinicopathologic prognostic variables, such as age (P=0.146), histological grade (P <0.001), tumor size (P <0.05), lymph node metastasis (P=0.476), AJCC stage (P=0.009), HER2 expression (p=0.077) on patients’survival (Table 1). This evidence concerns the gene ERBB2 and metastatic malignant neoplasm in the lymph nodes.