TEL-SYK over-expression in murine pre B cells causes a B-acute lymphocytic leukemia (ALL)-like disease in mice [23] and cytoplasmic TEL-SYK fusion induces an acute panmyelosis with myelofibrosis-type acute myeloid leukemia (AML) in a bone marrow transplantation model [24]. This evidence concerns the gene SYK and myelofibrosis.