The emergency of CAD is two to four times more frequent in diabetic patients than non-diabetic subjects, which implies the hidden mechanism of CAD risk in T2DM groups.[2] The serum levels of adiponectin, an adipocyte-derived hormone, are indicated to be associated with different metabolic syndrome [3], including obesity [4], type 2 diabetes [5], and insulin resistance [6]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.