ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The gene coding for adiponectin, ADIPOQ, is located on chromosome 3q27, which is the susceptible locus for CAD and T2DM.[10, 11] A wide range of anti-athergenic effects of adiponectin is reported.[12] Its genetic deficit could increase the risk of CAD in both general population and patients with type 2 diabetes.[13] Since plasma adiponectin level is affected by genetic factors such as single-nucleotide polymorphisms in the adiponectin gene (ADIPOQ), many studies about the associations between the polymorphisms of ADIPOQ and CAD, T2DM, Obesity and insulin resistance have been reported.