UHRF1 and Familial prostate cancer: At the cellular level, overexpression of UHRF1 has also been reported in aggressively proliferating, androgen-independent cell lines of prostate cancer (DU145 and PC3), while low expression of UHRF1 was found in immortalized normal prostate epithelial cells (LHS) or androgen-dependent prostate adenocarcinoma cells with low metastatic potential (LNCaP and 22Rv1 cells) [108, 109].