Targeting of UHRF1 also decreased the migration and invasion of cancer cells by hampering endothelial to mesenchymal transition (EMT) as evidenced by up regulation of (EMT opposing) E-cadherin and down regulation of (EMT favoring) β-catenin, vimentin, N-cadherin and snail in UHRF1 knockdown cells [92]. The gene discussed is UHRF1; the disease is cancer.