UHRF1 also confers radioresistance to breast cancer cells by promoting the expression of DNA damage repair proteins Lupus Ku autoantigen protein p70 (Ku-70) and Lupus Ku autoantigen protein p80 (Ku-80) repairing the chromosomal aberrations and also by down-regulating the expression of BAX and other pro-apoptotic proteins [100]. The gene discussed is UHRF1; the disease is breast cancer.