Using RNA-seq data and gene set enrichment analysis (GSEA), several deregulated pathways were identified; among them, attention was focused on the TGF-β signaling pathway, in view of its major role in the pathogenesis of AML [65–67] and because some TGF-β target genes were reported to be differentially expressed in aCML cells with mutated SETBP1 [2]. This evidence concerns the gene SETBP1 and acute myeloid leukemia.