SETBP1 and myeloid leukemia: Likewise, as the SETBP1 mutation seems to act in repressing the expression of some crucial differentiating genes such as RUNX1 via the recruitment of a nucleosome remodeling deacetylase, treatment with class I histone deacetylase (HDAC) inhibitors could be a promising strategy to treat human myeloid leukemias with SETBP1 activation [73].