ASXL1 and myelodysplastic syndrome: Furthermore, in an interesting study by Inoue et al. the relationship between mutations of SETBP1 and ASXL1 was explored, starting from the observation that in Myelodysplastic Syndrome (MDS) the high rate of co-occurrence of mutations resulted in a shorter OS and a higher incidence of leukemic transformation, and that the acquisition of the SETBP1 mutation in ASXL1-mutated MDS occurs during disease progression [60, 64].