In hematologic neoplasms, the discovery of SETBP1 as a new oncogene has helped to better define the molecular characteristics of pathologies such as atypical Chronic Myeloid Leukemia (aCML), a disease initially defined only by negative characteristics, like the absence of BCR-ABL1 fusion. Here, SETBP1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.