In summary, we demonstrated in this study that the DCA-induced COX2 impedes the antitumor effect of DCA in cervical cancer cells, and inhibition of COX2 by celecoxib can sensitize DCA in suppressing the growth of cervical cancer cells, which may pave a way for developing novel strategies for the treatment of cervical cancer using the combination of DCA and celecoxib. The gene discussed is PTGS2; the disease is cervical cancer.