To investigate the effect of FAK inhibitors or chemotherapy on CSCs in vivo, we treated mice bearing MDA-MB-231 (Figure 2B–2E) or SUM159 (Figure 2F–2I) triple-negative breast cancer (TNBC) tumors (200-400 mm3) with vehicle control (C), VS-4718, 100 mg/kg po bid for 10 days, VS-6063 50 mg/kg po bid for 10 days or paclitaxel 10 mg/kg ip at day 1. Here, PTK2 is linked to triple-negative breast carcinoma.