The expression levels of ADARB1 (P<0.01), ADRB2 (P<0.05) and ANKRD1 (P<0.05) were significantly down-regulated in stage I LUAD tissues; COL1A1 (P<0.05) and MMP13 (P<0.05) were significantly up-regulated in stage I LUAD tissues compared with adjacent non-tumor tissues (Figure 5G-5K). The gene discussed is MMP13; the disease is neoplasm.