The results of qRT-PCR showed that when compared with the blank and sham groups, IL-33 and ST2 mRNA expression increased, whereas miR-487b expression decreased in the CHF, NC of miR-487b mimic, NC of miR-487b inhibitor, NC of si-IL-33, and miR-487b inhibitor + si IL-33 groups (P < 0.05 for all). This evidence concerns the gene IL33 and congestive heart failure.