In the CHF, NC of miR-487b mimic, NC of miR-487b inhibitor, NC of si-IL-33, and miR-487b inhibitor + si IL-33 groups, the myocardial cells had hypertrophy and many green collagen fibers, were decreased in number, and were disorderly arranged in the intercellular space. This evidence concerns the gene IL33 and congestive heart failure.