Bevacizumab (Avastin, Genentech, South San Francisco, CA), a recombinant humanized monoclonal antibody against VEGF, has been widely used in the treatment of various cancers, including colorectal cancer, breast cancer, lung cancer, renal cell cancer, ovarian cancer, pancreatic cancer, gastric cancer, glioblastoma and so on [5–18]. The gene discussed is VEGFA; the disease is cancer.