BSG and metastasis: Without significant heterogeneity (P= 0.98, I2= 0%), fixed-effects model showed CD147 positive expression in lymph metastasis patient was more frequently than non-metastasis patient (96.77% vs. 76.34%) (OR= 6.52, 95%CI= (2.08, 20.38), P= 0.001) (Figure 4A).