Firstly, by combininginteracting with integrin alpha6beta1, CD 147 take part in FAK P13K-Ca (2+) and MARK signal pathway, interstitial collagenase (MMP-1) is producted and CD147-MMP-1 complex is formed at the tumor cell surface, thus modifying the tumor cell pericellular matrix to promote invasion [37–39]. Here, MARK1 is linked to neoplasm.