Interleukin-6 (IL6, GO term count=103), interleukin-18 (IL18, GO term count=73) and Interleukin-6 receptor (IL6R, GO term count=46) in top 10 genes of LMLncs (Figure 3F) have important roles in inflammation and many biological processes such as enhancing the power of tumor cell apoptosis, inhibiting tumorigenesis and inhibiting tumor angiogenesis [42, 43]. This evidence concerns the gene IL18 and neoplasm.