Many well-known lncRNAs have indicated tumor suppressive or oncogenic roles in various cancers, such as H19 [13], HOTAIR [14], MALAT1, MEG3 [15] and PVT1 [16] etc. LncRNA expression functions as good indicator of tumor stage, implying the potential role as independent biomarkers for prognosis prediction in cancers. The gene discussed is H19; the disease is cancer.