In the subgroup analysis by cancer type, FTO rs9939609 SNP risk allele marginally increased risk of endometrial cancer (OR=1.07, 95%CI=1.00-1.14) and pancreatic cancer (OR=1.12, 95%CI=1.04-1.21), while it marginally decreased risk of breast cancer (OR=0.94, 95%CI=0.92-0.96) (Table 2 and Supplementary Figure 1). This evidence concerns the gene FTO and breast cancer.