BRCA2 and ovarian cancer: This pathway includes several confirmed ovarian cancer susceptibility genes and we identified deleterious mutations in all 5 homologous recombination DNA repair genes known to be associated with predisposition to high-grade serous ovarian cancer: 36 in BRCA1 (8.7 percent), 26 in BRCA2 (6.3 percent), 2 in RAD51C (0.49 percent), 2 in RAD51D (0.49 percent) and 3 in BRIP1 (0.73 percent) (Supplementary Table 4).