The positive rate of E-cadherin protein was significantly lower in HCC than in adjacent non-tumor tissues (27.3% vs. 72.7%, P<0.05), and 66.9% (93/139) of the tumor tissues and 33.1% (46/139) of the adjacent non-tumor tissues showed high expression of N-cadherin. Here, CDH2 is linked to hepatocellular carcinoma.