Proteasome inhibitors such as the FDA approved dipeptide boronic acid analogue bortezomib (PS-341, Velcade®) or the irreversible inhibitor carfilzomib (PR-171, Kyprolis®) preferentially induce several apoptotic pathways and inhibition of transcription factors, including NF-κB or c-Myc, in cancer cells while sparing non-malignant cells. Here, MYC is linked to cancer.