In the other colon cancer models (Colo205 and HCT116), the apoptosis analysis confirmed the kinetic results, showing that the addition of GSEs didn't affect the cytotoxicity of oxaliplatin, as demonstrated by the persistent Annexin V/PI positive cells population (upper right quadrant), comparable to that of oxaliplatin given alone (Figure 4A). Here, ANXA5 is linked to malignant colon neoplasm.