EGR1 and neoplasm: The antitumor potential of CUR originates from its ability to block migration of many tumor cell lines, increase the expression of p53, p21 [20–24]; decrease the expression of Egr-1, activator protein-1 and NF-κB; suppress the expression of matrix metalloprotein-9, chemokines, LOX, cyclo-oxygen-ase-2, NOS, TNF, uPA and cyclin D1; suppress the activity of growth factor receptors; and reduce the expression of c- JNKs [25–31].