6 Squatrito Squatrito M M Brennan Brennan CW CW Helmy Helmy K K Huse Huse JT JT Petrini Petrini JH JH Holland Holland EC EC Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas Cancer Cell Cancer Cell 2010 2010 18 18 619 619 29 29 21156285 21156285. The gene discussed is CHEK2; the disease is central nervous system cancer.