The xenografted tumor sections were also used to evaluate the effect of CUR on phosphorylation of Chk1 and Cdc25c, and the results showed that CUR obviously induced phosphorylation of Chk1 and Cdc25c (Figure 6J–6L), which indicated that CUR can induce the activation of ATM and target ATM mediated signaling pathways. This evidence concerns the gene CHEK1 and neoplasm.