In support of this notion, others have shown that exposure of CD14+ peripheral blood mononuclear cells to breast cancer cell line-secreted factors increases their expression of the scavenger receptor CD163 and the OX-2 membrane glycoprotein, CD200R, while concomitantly decreasing their expression of the T-cell co-stimulatory molecule, CD86 [31]. This evidence concerns the gene CD200R1 and breast cancer.