BRCA1 and breast neoplasm: Validation analysis, performed by real-time PCR on an independent set of 19 familial (8 BRCA1/2-related and 11 BRCAX) and 10 sporadic BCs, showed a lower expression of miR-92a-1* in sporadic BCs compared to familial breast tumors (0.81 ± 0.16 vs 2.14 ± 0.6; p=0.12) and a statistically significant higher mean expression levels of miR-943 and miR-1184 in BCs without a positive family history compared with familial breast tumors subgroup (1.24 ± 0.44 vs 0.43 ± 0.06; p=0.02 and 1.21 ± 0.4 vs 0.27 ± 0.07; p=0.004, respectively) (Figure 4A).