The mean expression level of TGFB1 gene was higher in sporadic compared with familial BC (2.30 ± 0.29 vs 1.55 ± 0.21; p= 0.04), whereas the mean level of ATM transcript was lower in sporadic BC compared to breast tumors with a family history (0.72 ± 0.15 vs 2.72 ± 0.56; p= 0.001). This evidence concerns the gene ATM and breast neoplasm.