For example, previous study showed that the haplotype of IL1B, IL1RN, IL1R1, and IL1R2 increased the risk of venous thrombosis [11], and IL1/IL1Ra, CTLA-4 and Apo1/Fas genes polymorphisms associate with IgA nephropathy [12]. The gene discussed is IL1RN; the disease is Venous thrombosis.