USP5 and hepatocellular carcinoma: Intriguingly, with introduction of Dox or Cis, Usp5 knockdown suppressed (Figure 6A and 6B) while its overexpression promoted cell growth in the treated HepG2 cells and Bel7404 cells (Figure 6C and 6D), suggesting that Usp5 directs drug resistance in HCC cells.