Conversely, knockdown of Gas2 did not influence Calpain activity in G-CSF differentiated CML cells, but significantly increased Calpain activity in Lin−CD34+ CML cells (p < 0.01, n = 3; control versus CML) (Figure 4B). The gene discussed is CSF3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.