Calpain activity in Lin-CD34+ CML cells with Calpastatin knockdown was not significantly different than control Lin−CD34+ cells (p = 0.6, n = 3), but Calpastatin knockdown rescued Calpain activity G-CSF differentiated CML cells (Figure 4B). This evidence concerns the gene CAST and chronic myelogenous leukemia, BCR-ABL1 positive.