Similar to our studies of transduced murine bone marrow, Gas2 expression was significantly greater in Lin-CD34+ CML cells versus control Lin−CD34+ cells (p < 0.001, n = 3) and Calpastatin expression was significantly greater in CML cells undergoing granulocyte differentiation in comparison to similarly treated control cells (p < 0.001, n = 3) (Figure 1D). Here, CAST is linked to chronic myelogenous leukemia, BCR-ABL1 positive.