In this model, metformin treatment was associated with decreased tumor burden (p=0.0002) (Figure 1B), and presence of apoptosis in tumors, as evidenced by increased cleaved caspase-3 positive cells (Figure 1C) and total staining intensity (Figure 1D) of cleaved caspase-3 (p=0.011 and p=0.0003, respectively; Figure 1E shows a representative image of caspase-3 staining). Here, CASP3 is linked to neoplasm.