To define the clinical significance of PI3K/Akt/mTOR signaling in ALDEFLUORhigh CCSCs, we initially queried the Oncomine® database for the significance of ALDH1 overexpression in the Reid colorectal cancer patient data set (Compendia Bioscience, Ann Arbor, MI). The gene discussed is AKT1; the disease is colorectal cancer.