Accordingly, these evidences suggest that the up-regulation of the PPP3CA pathway via the C16orf74-PPP3CA interaction under the plasma membrane of PDAC cells should lead to constitutive nuclear-translocation and transcriptional activation of NFATs, resulting in up-regulation of cancer-related genes such as c-myc leading to enhancement of cell proliferation and invasiveness, although further elucidation of mechanism of NFATs signaling activation in C16orf74-overexpressing PDAC cells will be necessary. This evidence concerns the gene CLMB and cancer.