CLMB and familial pancreatic carcinoma: Because the EST sequence of the C16orf74 gene in the National Center for Biotechnology Information (NCBI) database (Accession: BE875115; 586bp) is smaller than the approximately 1-kb transcript shown in Figure 1B, we screened the full-length cDNA clone from a cDNA library prepared from pancreatic cancer cell lines (see Materials and Methods) and isolated three different isoforms (Figure 1C).