PSMB8 and infectious otitis media: During the course of AOM treatment and cyclic administration of DSS in drinking water, a profound body weight loss accompanied with occurrence of multiple tumors was observed in WT mice, whereas less significant loss of body weight, no visible adenocarcinomatous lesions and no loss of mucous-producing goblet cells were detectable in H&E or PAS-stained colonic tissue sections of LMP7 deficient animals (Figure 2A-2C).