Evidence to support a role for PPARγ in the development of the ER+ lineage was provided by transgenic mice expressing the fusion protein Pax8PPARγ, a dominant-negative form of PPARγ [4, 5], that is expressed in follicular thyroid cancer as a result of a t(2;3)(q13;p25) translocation between the paired-box transcription factor Pax8 and PPARγ [4]. The gene discussed is PPARG; the disease is thyroid gland follicular carcinoma.