IL6 and kidney disorder: As we know, IL‐6 classic signalling and trans‐signalling activate intracellular signalling via gp130 cascade but exhibit different properties in diseases including renal disorders 6, 27, 28, 29; therefore, we speculate whether the different phosphorylation forms of STAT3 are responsible for the distinct pathophysiological events of IL‐6 classic and trans‐signalling.