Moreover, treatment of PC cultured cells with the DNA methylation inhibitor 5‐aza‐2′‐deoxycytidine (decitabine) resulted in re‐expression of APC mRNA, APC protein, and reduced cell viability, thereby suggesting that decitabine could be an additional option in the treatment of patients with recurrent or metastatic PC (Svedlund et al., 2010). The gene discussed is APC; the disease is pachyonychia congenita.