However, a somatic TP53 missense mutation (c.743G > A, p.Arg248Gln) has been reported in anaplastic PC cells, but not in differentiated PC cells, suggesting an association between this TP53 mutation and anaplastic transformation (Hakim & Levine, 1994; Tamura et al., 2009). This evidence concerns the gene TP53 and pachyonychia congenita.