One candidate is 5T4, a trophoblast glycoprotein with restricted expression to several human adenocarcinomas, including more than 90% of CRCs. Previous studies demonstrated that 5T4-specific interferon-γ–positive (IFN-γ+) T-cell responses correlate with tumor stage, providing protection against metastasis. Here, TPBG is linked to adenocarcinoma.