In that context, overexpression of BRIL was highly efficacious to prevent infection by pseudovirion harboring Marburg and Ebola viruses’ entry proteins and to a much lower extent by influenza A. Another yet unexplored possibility would be for a bone-specific role of BRIL against arthritogenic alphaviruses like Ross River, Sindbis, and chikungunya viruses. Here, IFITM5 is linked to infection.