RTN4R and ischemic stroke: Although this correlative data shows indirect relationship between LOTUS expression and functional recovery, these findings are consistent with previous reports demonstrating neuronal reconstruction in CST and the other motor-related pathways in cerebral white matter or the brainstem, such as the corpus callosum, striatum, and the corticorubral tract, by blockade of NgR1-signaling for functional recovery after brain damage including ischemic stroke [7, 10, 11, 13, 28, 46].