Total hemoglobin increased 1.2–1.9 g/dL even as reticulocyte counts decreased, reflecting the better efficiency and quality of HbF-enriched erythropoiesis, also shown by improvements in biomarkers of hemolysis, thrombophilia, and inflammation (LDH, bilirubin, D-dimer, CRP). This evidence concerns the gene CRP and Rare hereditary thrombophilia.