The improvement in RBC quality produced by HbF induction thus explains improvements in thrombophilia biomarkers (D-dimer, Von Willebrand factor [vWF] propeptide, RBC adhesion to thrombospondin and laminin, SVCAM1 [endothelial damage biomarker]) in this and previous studies of decitabine, despite concurrent platelet count increases to >800 × 109/L [43]. This evidence concerns the gene VWF and Rare hereditary thrombophilia.