In 6‐OHDA‐lesioned PD model rats, levodopa treatment with the development of LID increased mushroom‐type spines in striatal SPNs.58 We previously demonstrated that levodopa treatment enlarged striatal drebrin immunoreactive dots (putative mushroom‐type dendritic spines) in LID model rats.50 Moreover, in another study, we found spine head enlargement in dSPNs of the CPu in the same LID model rats using fluorescent dye microinjection and confocal microscopy46 (Fig. 1). Here, DBN1 is linked to Parkinson disease.