This is consistent with previous studies that LGR5 was found to potentiate Wnt/β-catenin signaling in HEK293T cells and in Ewing sarcoma.34, 35 Furthermore, the self-renewal capacity of cervical cancer cells was decreased by DKK-1 or increased by CHIR-99021 (Figure 7). Here, DKK1 is linked to Ewing sarcoma.