LGR5 and colorectal cancer: Previous studies have documented that purified LGR5+ cells exhibit stem cell properties, and LGR5 has been widely accepted as a marker for tumor-initiating cells in colorectal cancer and epithelial ovarian cancer.23, 24 In the present study, first, we found that forced expression of LGR5 remarkably increased spheroid formation capacity in SiHa and HeLa cells.