LGR5 and cervical cancer: To determine whether upregulated LGR5 could greatly enhance the tumorigenic capacity of cervical cancer cells, the LGR5+ and LGR5– cell populations were sorted and purified, respectively, from LGR5-overexpressing cells and LGR5-AcGFP cells, and then, different doses of cells were subcutaneously injected into the flanks of NOD/SCID mice by limiting dilutions.