LGR5 and neoplasm: Inoculation with LGR5+ SiHa-LGR5 cells led a significantly shorter tumor-free period; for instance, the shortest tumor-free period following LGR5+ SiHa-LGR5 cell implantation was 5 weeks, compared with the 7-week tumor-free period exhibited by mice inoculated with LGR5– SiHa-AcGFP cells.