Similarly, the LGR5+ HeLa-LGR5 cells were associated with a significantly shorter tumor-free period (2 weeks for LGR5+ HeLa-LGR5 cells versus 4 weeks for LGR5– HeLa-AcGFP cells) and a lower tumor-free rate (18.75% for LGR5+ HeLa-LGR5 cells versus 75% for LGR5– HeLa-AcGFP cells) compared with the LGR5– HeLa-AcGFP cells (P<0.001). Here, LGR5 is linked to neoplasm.