LGR5 and neoplasm: To further investigate the mechanism involved in tumor promotion by LGR5 in cervical cancer, stable LGR5-overexpressing cells (SiHa-LGR5 and HeLa-LGR5) and stable LGR5-knockdown cells (SiHa-shLGR5 and HeLa-shLGR5) were established in cervical cancer cell lines.