TGFβ1 signalling is thought to be vital in blood vessel morphogenesis and stability.1 A number of cardiovascular disorders in humans are associated with mutations affecting TGFβ1 signalling, while in mouse knockout models involving components of TGFβ1 signalling lead to severe impairment of angiogenesis.2 However, the effects of TGFβ1 on angiogenesis are often contradictory since TGFβ1 has been observed to act as both a stimulator and an inhibitor of angiogenesis in vivo and in vitro. The gene discussed is TGFB1; the disease is cardiovascular disorder.