WNT4 and osteoporosis: On one hand, increased pro-inflammatory cytokines over-activates osteoclastogenesis which accelerates bone resorption.26, 27 On the other hand, aggravated inflammation increases oxidative stress and inhibits osteogenesis.28, 29 Wnt4 could prevent skeletal aging and inflammation by inhibiting NF-κB and ameliorates inflammation.17, 30 Thus, inhibiting osteoclastogenesis through anti-inflammation becomes an important strategy in osteoporosis treatment and screening the potential osteoclastogenesis inhibitor is a promising strategy for new anti-osteoporosis drug development.