Traditional Chinese herbs provide abundant resources for novel therapeutic agents for osteoporosis.31 Matrine, oxymatrine and derivatives have exhibited various pharmaceutical effects, including inhibition of inflammation,15 liver fibrosis16 and tumor growth.32 Based on matrine, we synthesized M19 that exhibited better anti-inflammatory effects than matrine.15, 16 In this study, we found that serum levels of TRAcp5B, TNF-α and IL-6 were significantly elevated in ovariectomized mice and decreased by M19 treatment. Here, TNF is linked to osteoporosis.