Its expression was also upregulated in metastatic as compared with matched primary tumors.63 MiR-10b directly targets the HOXD10 and Krüppel-like factor 4 genes.62, 64 MiR-21 is an oncogenic miRNA that inhibits several tumor-suppressor genes and thus promotes cell growth and invasion and tumor metastasis. The gene discussed is KLF4; the disease is neoplasm.