TNF and hepatocellular carcinoma: NF-κB has been related to initiation, promotion and progression of HCC.21, 22 Cezanne expression was shown to be rapidly induced by NF-κB signaling stimulated by TNF-α in a negative feedback manner.16 In addition, Cezanne negatively modulates NF-κB signaling pathway that has an important role in liver pathology.16, 23 Kanki et al.24 found that low Cezanne mRNA expression was correlated with poor prognosis for HCC patients.