SIRT7 and fatty liver disease: 37 A recent report showed that SIRT7 acted as an oncogene in gastric cancer and hepatocellular carcinoma.38, 39 Recently, SIRT7, the least-investigated member of the sirtuin family, has been a focus of research of diseases, such as hypertrophic inflammatory cardiomyopathy, fatty liver disease, oncogenic transformation, tumor growth, and age-related hearing loss.