SIRT7 is a member of the sirtuin family of histone deacetylases, the members of which have diverse roles in aging, DNA repair, cell cycle, metabolism, and disease biology.3, 4, 5 SIRT7 binds to the ribosomal RNA gene and is associated with reactivation of ribosomal DNA transcription following mitosis.6 Barber et al.7 revealed that SIRT7 is a NAD+-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells. The gene discussed is SIRT7; the disease is cancer.