Previously, we reported that FGF8 promoted cell proliferation in colorectal cancer cells.18 Considering that LRP6 is an essential Wnt coreceptor for activating the canonical Wnt/β-catenin signaling pathway,19 and FGF8, which was found in the LRP6-associated PPI network (Figure 3e), was a potential downstream gene of the Wnt pathway,20 the regulatory role of LRP6 on FGF8 expression in OSCC tissues was of particular interest. The gene discussed is LRP6; the disease is colorectal cancer.