It has been shown that the expression of LRP6 promote the proliferation rate of human fibrosarcoma HT1080 cells by altering the subcellular distribution of β-catenin.29 Another report revealed that the Wnt signaling was significantly activated in LRP6 transgenic mice, which contributed to the development of breast cancer.30 In this study, we showed that the proliferation rate of HSC-3 and Cal-27 OSCC cell lines were markedly inhibited after LRP6 knockdown, suggesting that LRP6 is probably a proproliferative factor in OSCCs. This evidence concerns the gene LRP6 and breast cancer.