LRP6 and neoplasm: As shown in Figure 4a, LRP6 signal was positively detected in both the cytoplasm and membrane, which were consistent with previous studies.15 Notably, strong LRP6 immunoreactivity was found in most tumor cases, whereas most of the cases of normal mucous exhibited only weak staining of LRP6 (t-test; OSCC N=51, normal N=28; P<0.001; Figure 4b).