Consistent with its effects on cytokine secretion, Reg3g overexpression also reduced tumor expressions of mRNAs for Th1 cytokines IFN-γ and IL-12, and increased mRNAs for Th2 cytokines such as TGF-β and IL-10 (Figure 1g and Supplementary Figure S1b). The gene discussed is TGFB1; the disease is neoplasm.