Its overexpression is marked by elevated levels of pancreatitis-associated protein.18 Our group has previously characterized the promotion by Reg3g of β-cell regeneration and immunosuppression in type 1 diabetes.14 We also reported that Reg3g accelerated malignant transformation in chronic pancreatitis and promoted pancreatic carcinogenesis partly via immunosuppressive action.8 The gene discussed is REG3G; the disease is chronic pancreatitis.