Patients with higher numbers of infiltrating mature DCs in resectable pancreatic cancer have more favorable outcomes.23, 24 DCs are potent antigen-presenting cells, and act as intermediaries between the tumor and the resultant T-cell response.25, 26 They are also involved in cross-priming CD8+ T cells,27, 28 which adds to the immune response by enhancing the expressions of MHC-II.29 Here, we report that Reg3g suppressed DC maturation markers MHC-II and the costimulatory molecule CD86, both in TBM and TME induced by administration of Panc02 cell-conditioned medium. This evidence concerns the gene REG3G and familial pancreatic carcinoma.