CD274 and pancreatic neoplasm: We also found that Reg3g overexpression lowered CD86 expression, enhanced endo-/phagocytic function determined by the extent of FITC-dextran upregulation, inhibited migration assessed by CCR7 downregulation, and increased expression of PD-L1 (Figure 1f) in DCs from bone marrow of the orthotopic pancreatic tumor mice.