The interplay between E-cadherin expression—a major tumour suppressor protein in epithelial cancers—and INSR/IGF1R signaling was found to modulate the expression of bisecting N-glycans (complex-type N-glycan containing bisecting β1,4-linked GlcNAc residue attached to a β-mannose), catalyzed by N-acetylglucosaminyltransferase III (GnT-III), encoded by the human MGAT3 gene [99]. This evidence concerns the gene IGF1R and neoplasm.