IGF1 and gastric cancer: In gastric cancer cells it has been shown that IGF1 is able to induce EMT through the up-regulation of ZEB2, in addition, AKT1/ERK inhibitors revert IGF1-induced EMT through up-regulation of miR-200c, suggesting the involvement of an AKT1/ERK-miR-200c-ZEB2 axis in EMT induced by IGF1 stimulation [45].