EGFR and neoplasm: The expression of branched N-glycans on the extracellular domain of cell surface receptors with a high number of N-glycosylation sites, such as on epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGFR), and fibroblast growth factor receptor (FGFR), promote the binding to galectins forming the molecular lattice that precludes the endocytosis of glycoprotein receptor, which consequently contributes to signaling activation and increased cell proliferation, tumour growth and oncogenesis [89,91,92].