IGFBP3 and non-small cell lung carcinoma: In NSCLC cells, hypoxia-induced EMT is accompanied by an increase of IGF1, IGF1R, and IGFBP3, whereas the treatment with AEW541 (IGF1R inhibitor) reverses hypoxia-induced EMT, and the inhibition of HIF1A with YC-1 inhibitor abolishes the activation of IGF1R and reduces the expression of IGF1 and IGFBP3 in hypoxic cells [68].