AKT1 and neuropathy: The formation of myelin abnormalities – a hallmark of numerous neuropathies (Dyck and Thomas, 2005) – may also involve mTORC1-independent targets of the PI3K-Akt pathway, given that such alterations accumulated substantially in MpzCreERT2:PtenKO, but less so in MpzCreERT2:Tsc1KO.