ADAM17 and neurodegenerative disease: Dysregulated activity of A Disintegrin And Metalloproteinase 17 (ADAM17)/TNFα Converting Enzyme (TACE) is associated with inflammatory disorders, cancer progression, and neurodegenerative disease by releasing regulatory membrane-tethered proteins like TNFα, IL6R and EGFR ligands (Arribas and Esselens, 2009; Gooz et al., 2009; Scheller et al., 2011; Rose-John, 2013).