Concerning this last mechanism, here we show that VP11/12 is not critical for Src and Dyn2 activation in neurons, but surprisingly partially contributes to GA fragmentation, suggesting that in addition to VP11/12, HSV-1 could use other viral proteins, to articulate Src and Dyn2 signaling, involved in the changes in the GA triggered by viral infection. This evidence concerns the gene DNM2 and viral infectious disease.