Concerning this last mechanism, here we show that VP11/12 is not critical for Src and Dyn2 activation in neurons, but surprisingly partially contributes to GA fragmentation, suggesting that in addition to VP11/12, HSV-1 could use other viral proteins, to articulate Src and Dyn2 signaling, involved in the changes in the GA triggered by viral infection. The gene discussed is SRC; the disease is viral infectious disease.