Injection of the STS cell lines in SCID mice resulted in tumor formation (87), and transcriptional profiling of Oncopig STS cell lines via RNA-seq identified transcriptional hallmarks of human STS, including altered TP53 signaling, Wnt signaling activation, and evidence of epigenetic reprogramming, including altered expression of DNA and histone methyltransferases (76). The gene discussed is TP53; the disease is telomere syndrome.