PRDM9 and telomere syndrome: Injection of the STS cell lines in SCID mice resulted in tumor formation (87), and transcriptional profiling of Oncopig STS cell lines via RNA-seq identified transcriptional hallmarks of human STS, including altered TP53 signaling, Wnt signaling activation, and evidence of epigenetic reprogramming, including altered expression of DNA and histone methyltransferases (76).