Current porcine models utilized for cancer research include an APC1311 porcine model of familial adenomatous polyposis that produces polyps but not tumors (79), a heterozygous TP53 knockout model of spontaneous osteosarcomas (80), and a chemically induced porcine HCC model, which takes over 1 year to develop clinically relevant tumors (81, 82). The gene discussed is TP53; the disease is cancer.